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KMID : 0352719990230010038
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Journal of Ginseng Research
1999 Volume.23 No. 1 p.38 ~ p.43
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Effect of Spinally Administered Ginseng Total Saponin on Capsaicin-Induced Pain and Excitatory Amino Acids-Induced Nociceptive Responses
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나성열/1Jin Ju Nah
1Yoon Hee Kim/1Seung Yeol Nah/2Seok Chang Kim/2Ki Yeul Nam/3Jong Keun Kim
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Abstract
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Ginseng total saponins (ginsenosides) are biologically active main ingredients of Panax ginseng. In present study, we have investigated whether pretreatment of ginsenosides inhibited capsaicin-induced pain at the spinal level, in the view that capsaicin causes substance P (SP) release from primary afferents. Ginsenosides relieved capsaicin-induced pain in a dose-dependent manner. The ED50 of the effect was 43 (20-93, 95% C.I.) μg/mouse. We investigated excitatory amino acids-induced nociceptive responses in mice, because these agents are also involved in nociceptive transmission in the spinal cord. Coadministration of ginsenosides with N-methyl-D-aspartate (NMDA) or kainate via i.t. inhibited NMDA- but not kainate-induced pain behaviors. The ED50 for the inhibition of NMDA-induced pain by ginsenosides was 37 (21-66, 95% C.I.) μg/mouse. These results suggest that the ginsenosides-induced antinociception results from blocking of pain transmitter-induced nociceptive information at the spinal level.
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KEYWORD
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Ginsenosides, NMDA, Substance P, Nociceptive response, Antinociciption, Postsynatic site,
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